Versatile Synthesis of Chiral Aminophosphine Phosphinites (AMPPs) as Ligands for Enantioselective Hydrogenation

Abstract

New chiral aminophosphine phosphinite (AMPP) ligands with different P-aryl substituents were prepared from (1R,3S,4S)-2-azabicyclo[2.2.1]hept-3-ylmethanol by a new and chemoselective synthetic approach. The ligands showed good enantioselectivity (up to 91%) in the Rh-catalyzed enantioselective hydrogenation of benchmark substrates.

Key words

hydrogenation - transition metals - asymmetric catalysis - amino alcohols - phosphorus

References

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This work is part of the Ph.D. thesis of Dubrovina, N. V.; Rostock, 2003.